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Spectral assignments for the aldose reductase inhibitor 4( S )‐2,3‐dihydro‐6‐fluoro‐2( R )‐methylspiro[chroman‐4,4′‐imidazoline]‐2′,5′‐dione and its synthetic intermediates
Author(s) -
Wang Mingan,
Mishra Manoj K.,
Zhu Wenjun,
Kador Peter F.
Publication year - 2005
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1697
Subject(s) - chemistry , aldose reductase inhibitor , chemical shift , carbon 13 nmr , stereochemistry , heteronuclear single quantum coherence spectroscopy , dept , aldose reductase , imidazoline receptor , coupling constant , two dimensional nuclear magnetic resonance spectroscopy , organic chemistry , enzyme , medicine , physics , particle physics
The 1 H and 13 C NMR chemical shifts of the aldose reductase inhibitor 4( S )‐2,3‐dihydro‐6‐fluoro‐2( R )‐methylspiro[chroman‐4,4′‐imidazoline]‐2′,5′‐dione, methylsorbinil, and its seven synthetic intermediates, have been completely assigned on the basis of DEPT, COSY, g‐HSQC and g‐HMBC. All CF coupling constants from one‐bond to four‐bond in the 13 C NMR spectra and HF and HH coupling constants from three‐bond to four‐bond in 1 H spectra were obtained. Copyright © 2005 John Wiley & Sons, Ltd.