Complete  1 H and  13 C NMR spectral assignment of  N ‐aralkylsulfonamides,  N ‐sulfonyl‐1,2,3,4‐tetrahydroisoquinolines and  N ‐sulfonyl‐2,3,4,5‐tetrahydro‐1 H ‐2‐benzazepines. Conformational analysis of  N ‐[((3′,4′‐dichlorophenyl)methyl)sulfonyl]‐3‐methyl‐2,3,4,5‐tetrahydro‐1 H ‐2‐benzazepin | Zendy

Jios Jorge L. | Zendy; Romanelli Gustavo P. | Zendy; Autino Juan Carlos | Zendy; Giaccio Héctor E. | Zendy; Duddeck Helmut | Zendy; Wiebcke Michael | Zendy

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Complete 1 H and 13 C NMR spectral assignment of N ‐aralkylsulfonamides, N ‐sulfonyl‐1,2,3,4‐tetrahydroisoquinolines and N ‐sulfonyl‐2,3,4,5‐tetrahydro‐1 H ‐2‐benzazepines. Conformational analysis of N ‐[((3′,4′‐dichlorophenyl)methyl)sulfonyl]‐3‐methyl‐2,3,4,5‐tetrahydro‐1 H ‐2‐benzazepin

Author(s) -

Jios Jorge L.,

Romanelli Gustavo P.,

Autino Juan Carlos,

Giaccio Héctor E.,

Duddeck Helmut,

Wiebcke Michael

Publication year - 2005

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.1657

Subject(s) - chemistry , sulfonyl , heteronuclear molecule , benzazepines , dept , stereochemistry , homonuclear molecule , heteronuclear single quantum coherence spectroscopy , carbon 13 nmr , two dimensional nuclear magnetic resonance spectroscopy , proton nmr , nuclear magnetic resonance spectroscopy , molecule , organic chemistry , alkyl

The complete and unambiguous assignment of the 1 H NMR and 13 C NMR spectra of 26 N ‐aralkylsulfonamides, N ‐sulfonyl‐1,2,3,4‐tetrahydroisoquinolines and N ‐sulfonylbenz[ c ]azepines was performed on the basis of APT, DEPT, homonuclear (gs‐COSY) and 1 H‐detected heteronuclear one‐bond (gs‐HMQC) and long‐range (gs‐HMBC) correlation experiments. The methylated 2,3,4,5‐tetrahydro‐1 H ‐2‐benzazepine derivative 26 adopts a chair conformation as determined by 1 H‐ 1 H coupling analysis and γ ‐gauche effects . This is supported by a single‐crystal X‐ray structure analysis. Copyright © 2005 John Wiley & Sons, Ltd.

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