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A simple approach for phase‐modulated single‐scan 2D NMR spectroscopy
Author(s) -
Andersen Nikolas Salisbury,
Köckenberger Walter
Publication year - 2005
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1624
Subject(s) - pulse sequence , spectroscopy , chemistry , nuclear magnetic resonance spectroscopy , ultrashort pulse , two dimensional nuclear magnetic resonance spectroscopy , chirp , phase (matter) , nuclear magnetic resonance , modulation (music) , signal (programming language) , sequence (biology) , pulse (music) , analytical chemistry (journal) , optics , physics , laser , acoustics , stereochemistry , biochemistry , organic chemistry , quantum mechanics , chromatography , detector , computer science , programming language
Conventional NMR spectroscopy techniques require long acquisition times due to the recovery time between the repeated excitations necessary for each increment of the evolution times in the indirectly detected dimensions. Here we outline a pulse sequence element for gradient‐assisted ultrafast multidimensional NMR spectroscopy using frequency‐modulated ‘chirp’ pulses to generate phase‐modulated magnetization in an indirectly detected spectral dimension. The potential of this sequence element is demonstrated by acquiring a correlation spectroscopy (COSY) spectrum in 96 ms. This new pulse sequence element is an extension of ultrafast spectroscopy techniques based on the generation of amplitude modulation of the NMR signal in the indirectly detected spectral dimensions. The use of phase modulation instead of amplitude modulation helps broaden the applicability and may provide an increase of sensitivity in some experiments due to the ability to distinguish between positive and negative frequency offsets relative to the carrier frequency of the sequence element. Copyright © 2005 John Wiley & Sons, Ltd.