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Structural and spectral assignment of three forskolin‐like diterpenoids isolated from Plectranthus ornatus
Author(s) -
Rijo Patrícia,
Fátima Simões M.,
Rodríguez Benjamín
Publication year - 2005
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1600
Subject(s) - chemistry , labdane , forskolin , stereochemistry , diterpene , acetone , two dimensional nuclear magnetic resonance spectroscopy , carbon 13 nmr , proton nmr , organic chemistry , biochemistry , receptor
Three labdane diterpenoids were isolated from an acetone extract of Plectranthus ornatus . Their structures, closely related to that of forskolin, were determined by NMR studies. Unambiguous and complete assignments of the 1 H and 13 C NMR chemical shifts for these substances are presented. The assignments are based on 2D shift‐correlated [ 1 H, 1 H‐COSY, 1 H, 13 C‐gHSQC‐ 1 J (C,H), 1 H, 13 C‐gHMBC‐ n J (C,H) ( n = 2 and 3)] and NOE experiments. Copyright © 2005 John Wiley & Sons, Ltd.