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1 H and 13 C NMR identification of unexpected 3,4‐dihydroquinoxalines in the syntheses of 1,5‐benzodiazepine derivatives
Author(s) -
Tjiou E. M.,
Lhoussaine E. G.,
Virieux D.,
Fruchier A.
Publication year - 2005
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1593
Subject(s) - chemistry , benzodiazepine , dehydroacetic acid , carbon 13 nmr , derivative (finance) , nmr spectra database , stereochemistry , medicinal chemistry , spectral line , organic chemistry , biochemistry , physics , receptor , astronomy , financial economics , economics
The reaction between o ‐phenylenediamines, dehydroacetic acid and aromatic aldehydes is shown to give not only the expected 1,5‐benzodiazepine derivative but also a 3,4‐dihydroquinoxaline, the structure of which was determined by its 1 H and 13 C 1D and 2D NMR spectra. Copyright © 2005 John Wiley & Sons, Ltd.