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NMR investigation of hydrogen bonding and 1,3‐tautomerism in 2‐(2‐hydroxy‐5‐substituted‐aryl) benzimidazoles
Author(s) -
Sridharan V.,
Saravanan S.,
Muthusubramanian S.,
Sivasubramanian S.
Publication year - 2005
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1588
Subject(s) - tautomer , chemistry , hydrogen bond , aryl , benzimidazole , ring (chemistry) , acetone , solvent , nuclear magnetic resonance spectroscopy , proton nmr , spectroscopy , medicinal chemistry , computational chemistry , organic chemistry , molecule , alkyl , physics , quantum mechanics
The 1,3‐tautomerism associated with 2‐(2‐hydroxy‐5‐substituted‐aryl)benzimidazoles was studied in different solvents. The effect of hydrogen bonding involving the hydroxyl group of the 2‐aryl ring on the tautomerism was investigated using NMR spectroscopy. The influence of the solvent concentration on 2‐(2‐hydroxy‐5‐chloroaryl)benzimidazole was studied in acetone‐ d 6 and DMSO‐ d 6 . Copyright © 2005 John Wiley & Sons, Ltd.