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Adiabatic pulses in 1 H– 15 N direct and long‐range heteronuclear correlations
Author(s) -
Hadden Chad E.
Publication year - 2005
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1543
Subject(s) - heteronuclear molecule , adiabatic process , chemistry , computational physics , nuclear magnetic resonance , analytical chemistry (journal) , physics , nuclear magnetic resonance spectroscopy , stereochemistry , quantum mechanics , chromatography
The application of adiabatic inversion pulses to the detection of 1 H– 15 N heteronuclear correlations is described. The pulse sequences studied were gHSQC, CRISIS‐gHSQC, gHMBC and CRISIS‐gHMBC. The poor inversion quality of rectangular 180° X pulses can lead to a loss of signal at the peripheries of the spectrum. Replacing these pulses with adiabatic sweeps significantly improves sensitivity across the potentially large 15 N spectral window. Satellite spectrum profiles are shown to demonstrate the increase in sensitivity when employing adiabatic pulses on wide spectral widths. Additionally, the active pharmaceutical nizatidine was used as a model compound to demonstrate the improvements in the long‐range correlation data. Copyright © 2004 John Wiley & Sons, Ltd.