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Piperidone derivative from Dalbergia sympathetica
Author(s) -
Shanmugam Nagarajan N.,
Priya Rao R,
Narayanan Manoj C.,
Gopalakrishnan Sethuraman M.
Publication year - 2005
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1516
Subject(s) - chemistry , dept , derivative (finance) , methylene , carbon 13 nmr , column chromatography , stereochemistry , medicinal chemistry , organic chemistry , financial economics , economics
An alcoholic extract of Dalbergia sympathetica , on column chromatography, yielded a compound which analyzed for C 6 H 11 NO 3 (M + 145). The IR spectrum of the compound showed the presence of carbonyl and hydroxyl groups. PMR, 13 C and DEPT NMR spectral studies of the compound showed the presence of one N ‐methyl, two methine and two methylene groups. A quaternary carbon signal at δ 172.88 ppm was assigned to C‐2 carbonyl of the compound. From all the above observations and also from the HMQC 2D NMR spectrum, the compound was identified as 3, 6‐dihydroxy‐ N ‐methyl‐2‐piperidone. This is the first report of the natural occurrence of this compound from plant sources. Copyright © 2004 John Wiley & Sons, Ltd.