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Structure determination of a sildenafil analogue contained in commercial herb drinks
Author(s) -
Shin Choonshik,
Hong Mooki,
Kim Daibyung,
Lim Yoongho
Publication year - 2004
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1467
Subject(s) - sildenafil , chemistry , piperazine , sulfonyl , stereochemistry , herb , high performance liquid chromatography , chromatography , organic chemistry , traditional medicine , medicinal herbs , medicine , alkyl
Abstract It was found from HPLC analysis that a commercial herb drink contains a putative sildenafil analog. In order to identify the sildenafil‐like compound, separation and purification were carried out. The structure determination was performed based on routine 1D and 2D NMR experiments. Unlike sildenafil, the compound contains an ethylpiperazine instead of a methylpiperazine group. In addition, the piperazine and phenyl groups are connected through an acetyl group instead of the sulfonyl group of sildenafil. Copyright © 2004 John Wiley & Sons, Ltd.