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Solid‐phase synthesis and 1 H and 13 C high‐resolution magic angle spinning NMR of 13 C‐labeled resin‐bound saccharides
Author(s) -
Loening Nikolaus M.,
Kanemitsu Takuya,
Seeberger Peter H.,
Griffin Robert G.
Publication year - 2004
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1364
Subject(s) - chemistry , magic angle spinning , carbon 13 nmr , nuclear magnetic resonance spectroscopy , magic angle , phase (matter) , analytical chemistry (journal) , crystallography , stereochemistry , organic chemistry
We show how high‐resolution magic angle‐spinning NMR spectroscopy can be used to characterize 13 C‐labeled saccharides that have been prepared using solid‐phase synthesis techniques while they are still bound to a solid‐support resin. With the use of 13 C‐labeled glucose as the starting material, we have successfully synthesized mono‐, di‐ and trisaccharides with uniform 13 C labeling of the saccharide rings. Using these materials, we have been able to assign the 13 C and 1 H spectra and to characterize various impurities on the resin beads. Copyright © 2004 John Wiley & Sons, Ltd.