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Broadband and band‐selective IMPRESS–gHMBC: compensation of refocusing inefficiency with synchronized inversion sweep
Author(s) -
Crouch Ronald,
Boyer Robert D.,
Johnson Ross,
Krishnamurthy Krish
Publication year - 2004
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1316
Subject(s) - broadband , adiabatic process , chemistry , inefficiency , spectral resolution , inversion (geology) , resolution (logic) , optics , computational physics , spectral line , physics , computer science , astronomy , artificial intelligence , thermodynamics , paleontology , structural basin , biology , economics , microeconomics
Compensation of refocusing inefficiency in a gHMBC experiment by replacing the rectangular π pulse with a pair of adiabatic pulses with synchronized inversion sweep (CRISIS) significantly improves the performance of the gHMBC experiment. The CRISIS–gHMBC experiment retains the pure absorptive shapes in F 1 and hence results in better lineshape and higher resolution than the current versions of magnitude mode gHMBC spectra. When used as a broadband experiment, CRISIS–gHMBC, owing to better refocusing efficiency of the adiabatic pulse pairs, gives improved performance across the 13 C spectral width. Moreover, it is shown that CRISIS–gHMBC is a robust and improved alternative and when used along with the IMPRESS (Improved Resolution using Symmetrically Shifted pulses) technique further increases the sensitivity and resolution without additional experimental time. The IMPRESS–CRISIS combination is demonstrated for broadband gHMBC and band‐selective gHMBC experiments. The ICbs–gHMBC [IMPRESS–CRISIS–band‐selective gHMBC] experiment is an attractive and better alternative to individual band‐selective gHMBC. Copyright © 2004 John Wiley & Sons, Ltd.