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Determination of enantiomeric excess by 13 C NMR spectroscopy
Author(s) -
Gogte V. N.,
Nanda R. K.,
Natu A. A.,
Pandit V. S.,
Sastry M. K.
Publication year - 1984
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270221006
Subject(s) - enantiomer , chemistry , nuclear magnetic resonance spectroscopy , reagent , spectroscopy , enantiomeric excess , oxazolidine , proton nmr , organic chemistry , enantioselective synthesis , catalysis , physics , quantum mechanics
Oxazolidine derivatives of β‐amino alcohols such as ephedrine have been resolved by 13 C NMR spectroscopy using Eu(hfc) 3 as a chiral shift reagent. The method is quantitative in the determination of enantiomeric excess, and is advantageous where 1 H NMR is of limited use owing, for example, to significant line broadening.