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Configurations and conformations of cis ‐ and trans ‐ N ‐methyl‐ and ‐ N ‐benzyl‐4,5‐ and ‐5,6‐tetramethylenetetrahydro‐1,3‐oxazines
Author(s) -
Sohár P.,
Fülöp F.,
Bernáth G.
Publication year - 1984
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270220811
Subject(s) - oxazines , chemistry , ring (chemistry) , homogeneous , stereochemistry , nuclear magnetic resonance spectroscopy , spectroscopy , atom (system on chip) , medicinal chemistry , organic chemistry , physics , quantum mechanics , thermodynamics , computer science , embedded system
The configurations and conformations of cis ‐ and trans ‐ N ‐methyl‐ and ‐ N ‐benzyl‐4,5‐ and ‐5,6‐tetramethylenetetrahydro‐1,3‐oxazines were determined by 1 H and 13 C NMR spectroscopy. The cis isomers are conformationally homogeneous, having the hetero atom attached to the cyclohexyl ring, in the axial and equatorial positions, respectively, in the 5,6‐ and 4,5‐tetramethylene compounds, similar to the case of the 2‐p‐nitrophenyl‐substituted analogues investigated previously.