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14 N NQR study of some local anesthetics
Author(s) -
Buess M. L.,
Bray P. J.
Publication year - 1984
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270220408
Subject(s) - nuclear quadrupole resonance , protonation , electrophile , nitrogen , chemistry , quadrupole , spectral line , nuclear magnetic resonance , atomic physics , physics , organic chemistry , quantum mechanics , ion , catalysis
Nitrogen‐14 nuclear quadrupole resonance (NQR) spectra for eleven local anesthetics in the solid state are reported and analyzed using the Townes and Dailey approach. The changes in the electron distributions at various nitrogen sites, produced by protonating the tertiary amino nitrogen, are discussed and shown to be in general agreement with expectations based on the increased electrophilic character of the protonated amino group.