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Barriers to rotation of the dimethylamino group in some 2‐amino‐4‐( N , N ‐dimethylamino)pyrimidines
Author(s) -
Wells C. H. J.
Publication year - 1982
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270200416
Subject(s) - rotation (mathematics) , chemistry , group (periodic table) , stereochemistry , crystallography , medicinal chemistry , polar effect , line (geometry) , organic chemistry , mathematics , geometry
The free energy of activation for rotation about the exocyclic CN bond of the dimethylamino group of some 6‐substituted 2‐amino‐4‐( N , N ‐dimethylamino)pyrmidines has been determined using 1 H NMR line shape analysis. The results are discussed in terms of the relative electron‐withdrawing and electron‐releasing effects of the substituents.