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Conformations of side chains of somatostatin very high field proton NMR studies
Author(s) -
Live David H.,
Davis Donald G.,
Agosta William C.,
Cowburn David
Publication year - 1982
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270190410
Subject(s) - side chain , spectral line , chemical shift , chemistry , field (mathematics) , nmr spectra database , proton , proton nmr , nuclear magnetic resonance spectroscopy , carbon 13 nmr satellite , nuclear magnetic resonance , crystallography , computational chemistry , physics , stereochemistry , fluorine 19 nmr , mathematics , pure mathematics , nuclear physics , quantum mechanics , polymer
Abstract The high field proton NMR spectra (500 and 600 MHz) of the peptide hormone somatostatin in D 2 O are reported. The results obtained are used to derive values of the couplings and chemical shifts related to the solution conformation of several of the side chains. This work resolves a discrepancy in the literature concerning the assignments of resonances in the spectrum. It also provides a means of testing the accuracy of obtaining values for these couplings and shifts in previous 2D NMR studies at lower field from strongly coupled multiplets in spectra of this complexity.