Premium
Assignment and analysis of the 500 MHz 1 H NMR spectra of somatostatin and the acyclic precursor (S 3,14 ‐Acm)‐somatostatin in dimethyl sulphoxide
Author(s) -
Deleuze C.,
Hull W. E.
Publication year - 1982
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270180214
Subject(s) - somatostatin , chemistry , aqueous solution , nmr spectra database , spectral line , chemical shift , stereochemistry , nuclear magnetic resonance , crystallography , physics , medicine , astronomy
The 500 MHz 1 H NMR spectra of somatostatin and the precursor, di‐S 3,14 ‐acetamidomethyl dihydrosomatostatin, in dimethyl sulphoxide solution have been assigned. Chemical shifts, coupling constants and NH shifts vs temperature coefficients are tabulated. The data are consistent with a stable β‐turn/β‐sheet conformation for the precurso, while somatostatin itself appears to be more conformationally mobile, with an average conformation significantly different from that in aqueous solution.