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Application of 1 H NMREu(fod) 3 shifted spectra for the determination of the enantiomeric composition and absolute configuration of secondary alcohols, using (−)‐ω‐camphanic esters
Author(s) -
Jurczak Janusz,
Konował Andrzej,
Krawczyk Zbigniew,
Ejchart Andrzej
Publication year - 1981
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270170112
Subject(s) - diastereomer , absolute configuration , chemistry , enantiomer , reagent , absolute (philosophy) , enantiomeric excess , composition (language) , organic chemistry , analytical chemistry (journal) , stereochemistry , enantioselective synthesis , catalysis , philosophy , linguistics , epistemology
The diastereomeric differences (Δδ) were measured for a series of 11 (−)‐ω‐camphanic esters of secondary alcohols of known absolute configuration, using 1 H NMR spectroscopy with Eu(fod) 3 as shift reagent. This method is convenient and useful for the measurement of enantiomeric compositions, whereas additional assumptions must be applied in determining the absolute configuration related to the signs of the diastereomeric differences.