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One‐bond C‐α,H coupling constants in amino acids and peptides pH dependence and substituent increments
Author(s) -
Egli Huldrych,
von Philipsborn W.
Publication year - 1981
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270150417
Subject(s) - sarcosine , tripeptide , chemistry , substituent , alanine , amino acid , glycine , alkyl , stereochemistry , hydrogen bond , medicinal chemistry , organic chemistry , molecule , biochemistry
One‐bond C‐α,H coupling constants are reported for glycine, alanine, sarcosine and related di‐ and tripeptides. A detailed study of the pH dependence of 1 J (C‐α,H) has led to a determination of additive increments, ζ, for the functional groups NH 3 , NHCO, COO − , and CONH which can be used, together with known values for NH 2 , COOH and alkyl substituents, to calculate 1 J (C‐α,H) in amino acids and peptides.