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14 N nuclear quadrupole resonance in nicotinic acid derivatives
Author(s) -
Kim N. S.,
Bray P. J.
Publication year - 1981
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270150411
Subject(s) - nicotinamide , nuclear quadrupole resonance , chemistry , nicotinic agonist , hydrogen bond , resonance (particle physics) , nitrogen , stereochemistry , nuclear magnetic resonance , enzyme , atomic physics , organic chemistry , molecule , biochemistry , physics , receptor
Nitrogen‐14 nuclear quadrupole resonance (NQR) spectra of nicotinic acid derivatives, known as antitumor agents, are reported and analyzed in the framework of the Townes and Dailey theory. A strong correlation exists between the charge difference σ NC − π at the pyridinic nitrogen and the inhibition of acetylcholinesterase by nicotinic acid derivatives, in which the inhibition potency (p I 50 ) increases as the charge difference σ NC − π increases. There are significant differences between 14 N NQR spectra for the pyridinic nitrogen sites of nicotinic acid and nicotinamide; these can be explained in terms of the differences in hydrogen bond lengths.