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15 N NMR spectroscopy 28 —solvent effects on the 15 N 13 C coupling constants of amides, imides, ureas and polypeptides
Author(s) -
Kricheldorf Hans R.
Publication year - 1980
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270140607
Subject(s) - chemistry , coupling constant , solvent , acetamide , phthalimide , solvent effects , crystallography , stereochemistry , organic chemistry , physics , particle physics
The 15 N 13 C coupling constants of 15 N‐enriched acetamide, N ‐acetylglycine anilide, phthalimide, α,α′‐bisphthalimido‐ p ‐xylene, N ‐methyl‐ N ′‐phenylurea, poly‐ L ‐alanine and poly‐ L ‐valine were measured in various solvents. It was found that the 15 N 13 C coupling constants depend largely on the nature of the solvent. Increasing acidity leads to higher one‐bond and lower two‐bond coupling constants. A change of concentration does not have any influence on the 15 N 13 C couplings while a large increase in temperature leads to a slightly lower 1 J (NC). It is concluded that solvent effects may limit the use of 15 N 13 C coupling constants for the elucidation of solvent‐induced conformational changes.