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15 N NMR spectroscopy 24 —chemical shifts and coupling constants of α‐amino acid N ‐carboxyanhydrides and related heterocycles
Author(s) -
Kricheldorf Hans R.
Publication year - 1980
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270140310
Subject(s) - chemical shift , chemistry , coupling constant , solvent , nuclear magnetic resonance spectroscopy , coupling (piping) , solvent effects , stereochemistry , crystallography , spectroscopy , computational chemistry , medicinal chemistry , organic chemistry , materials science , physics , particle physics , quantum mechanics , metallurgy
The chemical shifts of amino acid N ‐carboxyanhydrides (NCAs) and cyclic or linear urethanes are less sensitive to solvent effects than those of amides and lactams. The values of the one‐bond 15 N 1 H coupling constants depend on the solvent and are 5‐8 Hz larger than those of ureas and amides. The 15 N 13 C coupling constant of the NCO group is also unusually high, while that of the N—CH group lies within the range known for N ‐acylated aliphatic amines. The one‐bond 15 N 13 C coupling constant was found to be insensitive to conformational changes.