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Proton magnetic resonance studies of compounds with bridgehead nitrogen. 38 —solvent effects in the 1 H NMR spectra of nitrogen heterocyclic systems containing a 1,3‐arrangement of heteroatoms
Author(s) -
Crabb Trevor A.,
Jupp Philip A.
Publication year - 1980
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270130303
Subject(s) - chemistry , geminal , pyridine , heteroatom , methylene , solvent , solvation , solvent effects , proton , nitrogen , chemical shift , proton nmr , nmr spectra database , computational chemistry , spectral line , medicinal chemistry , organic chemistry , ring (chemistry) , physics , quantum mechanics , astronomy
Solvent effects on the 1 H NMR parameters of perhydro‐oxazolo[3,4‒ a ]pyridine, perhydropyrido[1,2‒ c ]‒[1,3]oxazine and perhydrothiazolo[3,4‒ a ]pyridine derivatives are described. Particularly marked are changes in the proton‐proton geminal coupling constants of the NCH 2 O and NCH 2 S methylene protons with solvent and these are attributed to reaction field and solvation effects rather than to changes in the position of conformational equilibria.