Premium
Carbon‐13 nuclear magnetic resonance studies of creatine, creatinine and some of their analogs
Author(s) -
Dietrich Robert F.,
Marletta Michael A.,
Kenyon George L.
Publication year - 1980
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270130202
Subject(s) - creatine , creatinine , chemistry , coupling constant , nuclear magnetic resonance , proton , carbon 13 , nuclear magnetic resonance spectroscopy , chemical shift , spectral line , analytical chemistry (journal) , stereochemistry , organic chemistry , biochemistry , physics , particle physics , quantum mechanics , astronomy
Creatine ( N ‐methyl‐ N ‐amidinoglycine), creatinine (1‐methyl‐2‐aminoimidazolin‐4‐one) and a series of 38 of their close structural analogs have been examined using natural abundance 13 C NMR spectroscopy at 25.16 MHz. Both proton‐coupled and proton noise‐decoupled spectra were recorded. Unequivocal assignments of the carbon resonances could be made in the vast majority of cases. Both 13 C NMR chemical shifts and 1 J (CH) values can be used to characterize and to differentiate readily between analogs of creatine and analogs of creatinine. For example, the 1 J (CH) coupling constants for the α‐carbons of the acyclic creatine analogs were all in the 140–142 Hz range, whereas the corresponding coupling constants for the related, cyclized creatinine analogs were all in the 150–152 Hz range.