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Tritium labelling of hexamethyldisiloxane for 3 H NMR referencing
Author(s) -
Long Mervyn A.,
Garnett John L.,
Lukey Christopher A.
Publication year - 1979
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270120910
Subject(s) - hexamethyldisiloxane , tritium , labelling , chemistry , proton nmr , radiochemistry , tritiated water , nuclear chemistry , chromatography , organic chemistry , plasma , biochemistry , nuclear physics , physics
Tritium labelled hexamethyldisiloxane is a suitable material for the internal referencing of 3 H NMR spectra. Such a referencing procedure is necessary where the instrument is not capable of scanning 1 H resonance under identical experimental conditions. Hexamethyldisiloxane may be tritiated to high activity (typically 1 Ci ml −1 ) by Raney nickel catalysed exchange with elemental tritium in a simple one‐step procedure. A variety of heterogeneous catalysts are shown to be inactive in the common labelling method involving exchange with tritiated water.