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A 13 C NMR study of tautomerism in phenoxymethylisoxazol‐5‐ones
Author(s) -
Auzou Gilles,
Rips Richard,
Likforman Joseph,
Hazebroucq Georges,
Aji Marc
Publication year - 1979
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270120203
Subject(s) - tautomer , chemistry , ring (chemistry) , pyridine , proton , solvent , computational chemistry , stereochemistry , medicinal chemistry , organic chemistry , physics , nuclear physics
A 13 C NMR study of new isoxazol‐5‐ones has been carried out in different solvents. Mathematical analysis of the tautomeric ring proton exchange in pyridine solvent indicates that the relative contributions of the NH, CH and OH tautomers are respectively 10 ± 5, 15 ± 3, 10 ± 8%, while the anionic form represents the remaining 65 ± 8%.