Determination of p K  a  values using  15 N and  13 C nuclear magnetic resonance spectroscopy. The case of apramycin | Zendy

Paschal Jonathan W. | Zendy; Dorman Douglas E. | Zendy

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Determination of p K a values using 15 N and 13 C nuclear magnetic resonance spectroscopy. The case of apramycin

Author(s) -

Paschal Jonathan W.,

Dorman Douglas E.

Publication year - 1978

Publication title -

organic magnetic resonance

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0030-4921

DOI - 10.1002/mrc.1270111210

Subject(s) - nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , chemistry , resonance (particle physics) , spectroscopy , molecule , physics , atomic physics , organic chemistry , quantum mechanics

By comparison of p K a values derived from 15 N and 13 C nuclear magnetic resonance (NMR) spectroscopies, the assignment of the 15 N resonances of apramycin is completed. 13 C NMR spectra appear to provide accurate p K a determinations with this aminoglycoside. Hydroxylation adjacent to one of the basic nitrogens of apramycin appears to change the p K a values of all five amines of the molecule.

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