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Determination of p K a values using 15 N and 13 C nuclear magnetic resonance spectroscopy. The case of apramycin
Author(s) -
Paschal Jonathan W.,
Dorman Douglas E.
Publication year - 1978
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270111210
Subject(s) - nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , chemistry , resonance (particle physics) , spectroscopy , molecule , physics , atomic physics , organic chemistry , quantum mechanics
Abstract By comparison of p K a values derived from 15 N and 13 C nuclear magnetic resonance (NMR) spectroscopies, the assignment of the 15 N resonances of apramycin is completed. 13 C NMR spectra appear to provide accurate p K a determinations with this aminoglycoside. Hydroxylation adjacent to one of the basic nitrogens of apramycin appears to change the p K a values of all five amines of the molecule.