Premium
Carbon‐13 magnetic resonance spectra of aldosterone, 18‐hydroxydeoxycorticosterone and 18‐hydroxyprogesterone
Author(s) -
Genard P.
Publication year - 1978
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270110912
Subject(s) - tautomer , dimer , aldosterone , chemistry , acetal , polar , spectral line , medicinal chemistry , crystallography , stereochemistry , organic chemistry , medicine , physics , astronomy
The 13 C NMR spectra of aldosterone in various solvents show the presence of only the tautomeric forms with hemi‐acetal (11–18) and hemi‐ketal (18–20) bridges. Solutions of 18‐hydroxy‐11‐deoxycorticosterone (6) and of 18‐hydroxyprogesterone in CDCl 3 contain mainly the hemi‐ketal (18–20) tautomer. Solutions of 6 in more polar solvents also contain—although to a lesser extent—a second form which may be a dimer or, more probably, a form representing two retamers with appreciable populations at the 21‐CH 2 OH group.