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Methyl substituent effects in the 13 C spectra of cyclohexanone O ‐methyl oximes and N , N ‐dimethylhydrazones
Author(s) -
Fraser Robert R.,
Dhawan Kasturi L.,
Taymaz Kevser
Publication year - 1978
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270110602
Subject(s) - substituent , chemistry , spectral line , cyclohexanone , medicinal chemistry , substitution (logic) , stereochemistry , crystallography , organic chemistry , physics , catalysis , astronomy , computer science , programming language
The 13 C NMR spectra of a series of 4‐ t ‐butylcyclohexane‐ O ‐methyl oximes and N , N ‐dimethylhydrazones containing α‐methyl substituents have been measured. The effects of α‐methyl substitution ( syn ‐axial, anti ‐axial and anti ‐equatorial) on the carbons α, β and γ to the substitution site are similar to those previously found in cyclohexanones. Use has been made of these substituent parameters to determine the conformational equilibria of the mobile 2‐methylcyclohexanone derivatives.