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Conformational study of diastereomers. V —assignment of RR and RS relative configurations to 2,2,6,6‐tetramethyl‐5‐phenyl‐3‐heptanol by proton n.m.r.
Author(s) -
Ibarra C. Alvarez,
Perez M. S. Arias,
Gonzalez F. Fernandez,
Sarompas M. Rico
Publication year - 1977
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270100158
Subject(s) - diastereomer , vicinal , steric effects , chemistry , coupling constant , stereochemistry , computational chemistry , physics , organic chemistry , particle physics
Abstract Assignment of RR and RS configurations to 2,2,6,6‐tetramethyl‐5‐phenyl‐3‐heptanol diastereomers has been carried out through an analysis of the observed values for vicinal coupling constants of both isomers and their conformational distribution. The latter was previously estimated from steric interaction energies between groups. Since the RR isomer is monoconformational its magnetic parameters can be used to carry out conformational analysis of related acyclic compounds.