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Stereochemical aspects of proton chemical shifts. VI —increments due to geminal hydroxyl, methyl substitution
Author(s) -
Tavernier Dirk,
Antunis Marc
Publication year - 1977
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270100154
Subject(s) - geminal , substitution (logic) , chemistry , hydrogen atom , proton , methyl radical , hydrogen , hydroxyl radical , medicinal chemistry , stereochemistry , computational chemistry , radical , organic chemistry , group (periodic table) , physics , quantum mechanics , computer science , programming language
In geminal methyl, hydroxyl substitution an axial hydroxyl, equatorial methyl arrangement has a downfield effect on a syn axial hydrogen atom which is larger by 0.3 ppm than an axial methyl, equatorial hydroxyl arrangement. It is proposed that these observations may constitute a basis for configurational assignment.