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13 C n.m.r. spectra of lysergic acid derivatives: II—dihydrolysergamides
Author(s) -
Zetta L.,
Gatti G.
Publication year - 1977
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270090409
Subject(s) - substituent , piperidine , chemistry , lysergic acid , chemical shift , ring (chemistry) , amide , stereochemistry , solvent , cyclohexane conformation , spectral line , crystallography , molecule , hydrogen bond , organic chemistry , physics , astronomy
The conformations of dihydrolysergamides and 10‐methoxydihydrolysergamides have been inferred from the study of the chemical shifts of the amide hydrogens and their temperature dependence. The 13 C chemical shifts have been shown to be sensitive to conformational changes of the piperidine ring. The results indicate that the conformation of the latter depends both on the substituent in position 10 and on the solvent.