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13 C n.m.r. investigation on the nitrogen methylation of some azabenzenes
Author(s) -
Van De Weijer Peter,
Mohan Chandra
Publication year - 1977
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270090111
Subject(s) - pyrazine , pyridazine , pyridine , pyrimidine , methylation , chemistry , protonation , nitrogen , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , ion , gene
The 1 H and 13 C n.m.r. spectra of N ‐methylated pyridine, pyridazine, pyrimidine and pyrazine and N , N ‐dimethylated pyrimidine and pyrazine have been recorded and analysed. The change in the 13 C chemical shifts under the influence of N ‐methylation (Δδ) in the diazabenzenes could be predicted by the Δδ values of pyridine. A comparison of the Δδ values of N ‐methylation with those of N ‐protonation showed that both reactions have a similar effect.