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Variable temperature n.m.r. behaviour of 1,5‐benzodiazepinones and 1,5‐benzodiazepinthiones
Author(s) -
Benassi Rois,
Lazzeretti Paolo,
Taddei Ferdinando,
Nardi Dante,
Tajana Alberto
Publication year - 1976
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270080715
Subject(s) - ring (chemistry) , variable (mathematics) , chemistry , inversion (geology) , mathematics , mathematical analysis , organic chemistry , geology , geomorphology , structural basin
The n.m.r. variable temperature behaviour of the 7‐membered ring in 1,3‐dihydro‐2 H ‐1,5‐benzodiazepin‐2‐one derivatives and in the corresponding 2‐thiones has been investigated. The results indicate that the ring inversion barrier is higher in the thiones and dependent on substituents bonded at N‐1. The activation parameters are obtained and discussed.