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Proton magnetic resonance spectra of some 6‐ and 7‐substituted 2‐amino‐4‐hydroxypteridines
Author(s) -
Storm Carlyle B.,
Chung Hyang S.
Publication year - 1976
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270080708
Subject(s) - substituent , ring (chemistry) , pyrazine , proton magnetic resonance , chemistry , spectral line , resonance (particle physics) , nuclear magnetic resonance , stereochemistry , crystallography , proton , position (finance) , physics , atomic physics , organic chemistry , finance , astronomy , quantum mechanics , economics
The conformations in solution of 6‐phenyltetrahydropterin, 6,7‐diphenyltetrahydropterin and 6‐7, dimethyltetrahydropterin have been determined from their proton magnetic resonance spectra. The 6‐phenyltetrahydropterin has the reduced pyrazine ring in a half chair conformation with the phenyl ring in the equatorial position. Both the 6,7‐diphenyl‐ and 6,7‐dimethyltetrahydropterins are of the cis configuration and have one substituent in an axial position. The enzymatic activity of these cofactors may be related to these conformations.