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Long range 13 C 1 H coupling constants IV —methoxy‐, amino‐ and hydroxypyridines
Author(s) -
Takeuchi Yoshito,
Dennis Nicholas
Publication year - 1975
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270070509
Subject(s) - chemistry , tautomer , coupling constant , proton , range (aeronautics) , carbon 13 , computational chemistry , medicinal chemistry , physics , nuclear physics , materials science , composite material , particle physics
One bond and long range 13 C 1 H coupling constants for some methoxy‐, amino‐ and hydroxypyridines are described. An unambiguous assignment of carbon‐13 resonances is carried out based on the analysis of the fine splitting caused by long range couplings. J values for compounds other than 2‐ and 4‐hydroxy‐pyridines are explainable in terms of the values previouly obtained for cyano‐ and methylpyridines. The hydroxypyridine‐pyridone tautomerism affects 2 J (H α ), i.e. 2 J associated with the α proton. This effect can be used to differentiate pyridones from hydroxypyridines.