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Restricted rotation in amides. VII —methods of resonance assignment in tertiary amides —an evaluation
Author(s) -
Lewin Anita H.,
Frucht Melvin
Publication year - 1975
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270070505
Subject(s) - lanthanide , chemistry , solvent , polar , resonance (particle physics) , carboxamide , tertiary care , nuclear magnetic resonance , organic chemistry , physics , ion , medicine , family medicine , particle physics , astronomy
Examination and evaluation of various methods for resonance assignments in amides reveals that only three of these are reliable: (a) the nuclear Overhauser effect, which leads to unequivocal results in tertiary amides; (b) the aromatic solvent induced shift, which is rapid and accurate for tertiary amides without polar substituents; (c) the lanthanide‐induced shift, which although easy, can be applied only to tertiary amides with substituents that do not complex lanthanides.