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NMR determination of the enantiomer composition of penicillamine using an optically active europium shift reagent
Author(s) -
Cockerill Anthony F.,
Davies Geoffrey L. O.,
Harrison Roger G.,
Rackham David M.
Publication year - 1974
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270061214
Subject(s) - penicillamine , europium , enantiomer , chemistry , reagent , tris , optically active , composition (language) , combinatorial chemistry , chromatography , organic chemistry , biochemistry , ion , linguistics , philosophy
An NMR method is described for assaying the enantiomer composition of the pharmacologically active material penicillamine ( 1 ), using tris‐(3‐heptafluorobutyryl‐ d ‐camphorato)europium. The L enantiomer can be detected at levels of 0·4 to 0·5% in DL mixtures. Problems due to the insolubility of penicillamine in nonpolar solvents can be overcome by a two step derivatisation procedure.