NMR determination of the enantiomer composition of penicillamine using an optically active europium shift reagent | Zendy

Cockerill Anthony F. | Zendy; Davies Geoffrey L. O. | Zendy; Harrison Roger G. | Zendy; Rackham David M. | Zendy

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NMR determination of the enantiomer composition of penicillamine using an optically active europium shift reagent

Author(s) -

Cockerill Anthony F.,

Davies Geoffrey L. O.,

Harrison Roger G.,

Rackham David M.

Publication year - 1974

Publication title -

organic magnetic resonance

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0030-4921

DOI - 10.1002/mrc.1270061214

Subject(s) - penicillamine , europium , enantiomer , chemistry , reagent , tris , optically active , composition (language) , combinatorial chemistry , chromatography , organic chemistry , biochemistry , ion , linguistics , philosophy

An NMR method is described for assaying the enantiomer composition of the pharmacologically active material penicillamine ( 1 ), using tris‐(3‐heptafluorobutyryl‐ d ‐camphorato)europium. The L enantiomer can be detected at levels of 0·4 to 0·5% in DL mixtures. Problems due to the insolubility of penicillamine in nonpolar solvents can be overcome by a two step derivatisation procedure.

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