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Substituent effects in proton NMR of monosubstituted acetophenones: I
Author(s) -
Caplin G. A.
Publication year - 1974
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270060210
Subject(s) - substituent , chemical shift , chemistry , proton , computational chemistry , proton nmr , medicinal chemistry , stereochemistry , physics , nuclear physics
Chemical shifts are reported for the acetyl protons in a series of para ‐substituted acetophenones in a number of solvents, and substituent effects evaluated statistically by means of the Swain‐Lupton multiple correlation analysis. A basic set of substituents was built up by careful choice of substituted derivatives, and it was shown that this facilitated the possibility of valid comparisons of substituent effects between differing systems. Strong emphasis was placed on the idea of individuality of substituents and solvents.