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NMR studies of viomycin
Author(s) -
Viglino P.,
Franconi C.,
Lai A.,
Brosio E.,
Conti F.
Publication year - 1972
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270040205
Subject(s) - viomycin , intramolecular force , chemistry , spectral line , nmr spectra database , hydrogen bond , molecule , crystallography , computational chemistry , stereochemistry , physics , organic chemistry , antibiotics , biochemistry , streptomycin , astronomy
The 1 H and 13 C NMR spectra of antibiotic Viomycin sulphate and its constituent aminoacids in H 2 O and D 2 O were examined in a wide range of pH values. The spectra were analysed by proton spin‐spin decoupling experiments and measurements of the relative intensities of the resonance and chemical shift values. Exchange experiments were also carried out and an almost complete assignment of the resonances of the spectra was possible. The data obtained are discussed in terms of possible structures for Viomycin and the presence of intramolecular hydrogen bonds. Some information about the conformation of the molecule is also given. A tentative assignment of the 13 C spectrum of Viomycin is given and the experimental 13 C chemical shift values compare well with the theoretical ones evaluated by Grant's rule.