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Solvent effects in nuclear magnetic resonance spectra of some pyrazines, pyrimidines and their N‐oxides
Author(s) -
Paudler William W.,
Humphrey Sharon A.
Publication year - 1971
Publication title -
organic magnetic resonance
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0030-4921
DOI - 10.1002/mrc.1270030207
Subject(s) - chemical shift , solvent , benzene , chemistry , proton , proton magnetic resonance , spectral line , solvent effects , photochemistry , solvent exposure , organic chemistry , nuclear magnetic resonance , physics , quantum mechanics , astronomy
The benzene‐induced solvent effects upon the proton chemical shifts of various pyrazines, pyrimidines and their N ‐oxides are described. Larger chemical shift effects, implying closer benzeneheterocycle association, are noted in the N ‐oxides as compared to the non‐oxidized heterocycles. The solvent‐induced chemical shift changes can be used to establish the site of N ‐oxidation in those instances where different isomers can be formed.