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Pharmacological compartment viscosity and polarity measured with very low‐frequency EPR in tumors of living animals
Author(s) -
Halpern Howard J.,
Chandramouli G. V. R.,
Yu Cheng,
Peric Miroslav,
Barth Eugene D.,
Teicher Beverly A.,
Grdina David
Publication year - 1995
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260331322
Subject(s) - chemistry , electron paramagnetic resonance , viscosity , nuclear magnetic resonance , compartment (ship) , electron paramagnetic resonance spectroscopy , biophysics , analytical chemistry (journal) , chromatography , thermodynamics , oceanography , physics , biology , geology
Quantitative measurements of the viscosity of a non‐vascular pharmacological compartment in a living animal are presented. Using novel, very low‐frequency electron paramagnetic resonance spectroscopy, capable of measurements in humans, novel analytical techniques and partially deuterated spin probes, the viscosity of the body water of murine fibrosarcomas implanted in the leg of a living animal were measured. The average viscosity was 1.9 ± 0.2 cP. Variation of the viscosity with tumor size and histology did not appear to be significant.