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Analysis of 13 C NMR substituent chemical shifts in some (aryl)(2‐nitrobenzo [ b ]thiophen‐3‐yl)amines: A new class of compounds with analgesic, anti‐exudative and anti‐inflammatory activities showing low mutagenicity
Author(s) -
Lamartina Liliana,
Spinelli Domenico,
Guerrera Francesco,
Sarvà Maria Concetta
Publication year - 1995
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260331108
Subject(s) - chemistry , substituent , aryl , chemical shift , carbon 13 nmr , proton nmr , analgesic , stereochemistry , medicinal chemistry , organic chemistry , alkyl , medicine , pharmacology
The 13 C NMR chemical shift values of (aryl)(2‐nitrobenzo[ b ]thiophen‐3‐yl)amines were measured in DMSO‐ d 6 solutions, suggesting the occurrence of an alternate charge polarization at C‐3, C‐2, C‐3a, C‐7a, C‐4 and C‐5. A dual substituent parameter analysis of the experimental data indicates a large or a low resonance contribution for aryl para or meta substituents, respectively, while the inductive component remains constant throughout.