Structural elucidation of rokitamycin, midecamycin and erythromycin metabolites formed by pathogenic  Nocardia | Zendy

Morisaki Naoko | Zendy; Iwasaki Shigeo | Zendy; Furihata Kazuo | Zendy; Yazawa Katsukiyo | Zendy; Mikami Yuzuru | Zendy

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Structural elucidation of rokitamycin, midecamycin and erythromycin metabolites formed by pathogenic Nocardia

Author(s) -

Morisaki Naoko,

Iwasaki Shigeo,

Furihata Kazuo,

Yazawa Katsukiyo,

Mikami Yuzuru

Publication year - 1995

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.1260330613

Subject(s) - chemistry , erythromycin , glycosylation , hydrolysis , nocardia , stereochemistry , microbiology and biotechnology , antibiotics , biochemistry , bacteria , biology , genetics

Pathogenic Nocardia spp. converted rokitamycin, midecamycin and erythromycin into inactive metabolites, the structures of which were determined from NMR and mass spectral data. Depending on the species of Nocardia , these macrolides underwent phosphorylation at 2′‐OH, hydrolysis of the 4″‐O‐acyl group, glycosylation at 2′‐OH and/or reduction of the 18‐formyl group. Full 1 H and 13 C assignments are presented and some solvent effects are described.

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