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Structural elucidation of rokitamycin, midecamycin and erythromycin metabolites formed by pathogenic Nocardia
Author(s) -
Morisaki Naoko,
Iwasaki Shigeo,
Furihata Kazuo,
Yazawa Katsukiyo,
Mikami Yuzuru
Publication year - 1995
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260330613
Subject(s) - chemistry , erythromycin , glycosylation , hydrolysis , nocardia , stereochemistry , microbiology and biotechnology , antibiotics , biochemistry , bacteria , biology , genetics
Pathogenic Nocardia spp. converted rokitamycin, midecamycin and erythromycin into inactive metabolites, the structures of which were determined from NMR and mass spectral data. Depending on the species of Nocardia , these macrolides underwent phosphorylation at 2′‐OH, hydrolysis of the 4″‐O‐acyl group, glycosylation at 2′‐OH and/or reduction of the 18‐formyl group. Full 1 H and 13 C assignments are presented and some solvent effects are described.