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Demonstration of the linear dependence of proton magnetization transfer on polymer concentration in aqueous gels at two different field strengths
Author(s) -
Tessier Jean J.,
Potter Kimberlee,
Carpenter T. Adrian,
Hall Laurance D.,
Tyler Jenny A.
Publication year - 1994
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260320112
Subject(s) - chemistry , aqueous solution , magnetization transfer , polymer , magnetization , proton , calcium , intermolecular force , relaxation (psychology) , sodium , ion , analytical chemistry (journal) , chemical engineering , chemical physics , chromatography , organic chemistry , molecule , magnetic field , quantum mechanics , magnetic resonance imaging , engineering , radiology , medicine , psychology , social psychology , physics
Saturation transfer experiments were performed at both 85 and 300 MHz to measure the magnetization transfer (MT) rate as a function of macromolecular concentration. For this purpose calcium alginate gels with an internal concentration gradient were manufactured from aqueous sodium alginate and calcium ions. Although aqueous sodium alginate did not exhibit any MT, the proton magnetization transfer rate in calcium alginate gels was found to depend linearly on the concentration of polysaccharide. Since the rate did not depend on the field strength, the dominant mechanism of MT in these systems is either chemical exchange or a highly efficient intermolecular cross‐relaxation process. The high sensitivity of MT to variation in polysaccharide concentration and mobility suggests that it is an excellent tool to monitor changes in the chemistry, mobility and concentration of slowly moving polymers in aqueous gels.