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Investigation of the dynamics of cyclodextrins and their inclusion complexes in water by deuterium NMR
Author(s) -
AzaroualBellanger Nathalie,
Perly Bruno
Publication year - 1994
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260320103
Subject(s) - chemistry , deuterium nmr , deuterium , dynamics (music) , inclusion (mineral) , nuclear magnetic resonance spectroscopy , computational chemistry , organic chemistry , mineralogy , nuclear physics , physics , acoustics
Deuterium NMR and relaxation data are presented to investigate the state of β‐cyclodextrin in aqueous solution and to derive dynamic parameters for inclusion complexes. Labelled host and guest molecules were used, and dedicated pulse sequences are proposed for improving the deuterium spectra in terms of reduction of artifacts and of solvent peak(s) and also in terms of total duration of the experiments. This technique was used to investigate the state of β‐cyclodextrin in aqueous solution and to derive important information regarding the degree of dynamic coupling between host and guest in inclusion complexes.