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Carbon‐13 NMR investigation of some substituted 1,3‐thiazolidin‐4‐ones
Author(s) -
Woolston Christopher Richard Joseph,
Lee John Barry,
Swinbourne Frederick John
Publication year - 1993
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260310407
Subject(s) - chemistry , methylene , chemical shift , ring (chemistry) , carbon 13 nmr , nmr spectra database , medicinal chemistry , stereochemistry , nuclear magnetic resonance spectroscopy , relaxation (psychology) , spectral line , organic chemistry , psychology , social psychology , physics , astronomy
The 13 C NMR spectra of a series of 2,3‐diaryl‐1,3‐thiazolidin‐4‐ones were measured and the resonance signals produced by the methylene, methine and carbonyl groups of the heterocyclic ring assigned. The variations in their chemical shifts were examined and the influence of S ‐oxidation was investigated. 3‐Benzyl‐2‐phenyl‐1,3‐thiazolidin‐4‐one, 3‐butyl‐2‐phenyl‐1,3‐thiazolidin‐4‐one and 2,3‐diphenyl‐5‐methyl‐1,3‐thiazolidin‐4‐one were also examined, the last compound being shown to exist as a mixture of isomers. T 1 relaxation times were determined for three thiazolidinones and related to structural effects.