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Strategies for the phase editing of relayed responses in 2D HMQC‐TOCSY spectra
Author(s) -
Crouch Ronald C.,
Spitzer Timothy D.,
Martin Gary E.
Publication year - 1992
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260301315
Subject(s) - chemistry , vicinal , multiplicity (mathematics) , spectral line , pulse sequence , proton , proton nmr , two dimensional nuclear magnetic resonance spectroscopy , phase (matter) , dept , nmr spectra database , carbon 13 nmr , chemical shift , stereochemistry , crystallography , nuclear magnetic resonance , physics , organic chemistry , mathematical analysis , nuclear physics , mathematics , astronomy
An NMR technique for the determination of proton vicinal couplings relayed at the carbon chemical shift is presented. With this technique, which is an extension of DEPT‐HMQC‐TOCSY, it is possible to generate phaseedited 2D NMR data in which the 1 H 13 C relayed responses differ in phase as a function of the proton multiplicity of the carbon from whose proton(s) the response originates. A simple pulse scheme is presented to allow further simplification of the spectrum by eliminating the direct 1 H 13 C correlations. Thus, responses arising from methines or methyls will be of opposite phase from responses originating from methylenes; direct correlations are eliminated to minimize congestion. An example is presented with the cardiac drug digoxin.