Premium
Structural studies on clarithromycin (6‐ O ‐methylerythromycin A): Assignments of the 1 H and 13 C NMR spectra in organic and aqueous solutions
Author(s) -
Awan Abida,
Barber Jill,
Brennan Richard J.,
Parkinson John A.
Publication year - 1992
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260301213
Subject(s) - chemistry , clarithromycin , aqueous solution , ketone , nmr spectra database , spectral line , erythromycin , nuclear magnetic resonance spectroscopy , medicinal chemistry , stereochemistry , organic chemistry , antibiotics , biochemistry , physics , astronomy
Full assignments of the 1 H and 13 C NMR spectra of clarithromycin (6‐ O ‐methylerythromycin A) in CDCl 3 and buffered D 2 O were carried out. In contrast to erythromycin A, clarithromycin exists as a single isomer, the 9‐ketone, in aqueous solution.