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Proton NMR investigation of some substituted 1,3‐thiazolidin‐4‐ones
Author(s) -
Woolston Christopher Richard Joseph,
Lee John Barry,
Swinbourne Frederick John,
Thomas William Anthony
Publication year - 1992
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.1260301109
Subject(s) - chemistry , chemical shift , coupling constant , ring (chemistry) , proton , abx test , proton nmr , carbon 13 nmr satellite , spectral line , nmr spectra database , computational chemistry , stereochemistry , nuclear magnetic resonance spectroscopy , crystallography , fluorine 19 nmr , organic chemistry , physics , statistics , mathematics , particle physics , quantum mechanics , astronomy
The 1 H NMR spectra of a series of 2,3‐diaryl‐1,3‐thiazolidin‐4‐ones were measured and the ABX systems due to the heterocyclic ring protons were formally analysed. The chemical shifts and coupling constants were examined in relation to the structures concerned. The effects of S‐oxidation of these compounds on the spectral parameters were investigated. The 1 H chemical shifts of 3‐benzyl‐2‐phenyl‐1,3‐thiazolidin‐4‐one and 3‐butyl‐2‐phenyl‐1,3‐thiazolidin‐4‐one suggested the presence of a preferred conformation about the NCH 2 bond.